{"id":20052,"date":"2022-09-01T00:00:00","date_gmt":"2025-02-15T06:40:39","guid":{"rendered":"https:\/\/bvtn.edu.vn\/?post_type=nghien-cuu&#038;p=20052"},"modified":"2025-02-15T13:41:09","modified_gmt":"2025-02-15T06:41:09","slug":"10-1016-j-jsamd-2022-100503","status":"publish","type":"nghien-cuu","link":"https:\/\/bvtn.edu.vn\/en\/nghien-cuu\/10-1016-j-jsamd-2022-100503\/","title":{"rendered":"Fabrication of in situ crosslinking hydrogels based on oxidized alginate\/N,O-carboxymethyl chitosan\/\u03b2-tricalcium phosphate for bone regeneration"},"comment_status":"open","ping_status":"closed","template":"","meta":{"update-doi":"false","doi":"10.1016\/j.jsamd.2022.100503","first-author":"Binh Thanh Vu","authors":"Binh Thanh Vu, Van My Hua, Tuan-Ngan Tang, Nhi Ngoc-Thao Dang, Hang Thi-Thuy Cao, Thang Bach Phan, Hanh Thi-Kieu Ta, Viet Hung Pham, Quyen Ngoc Tran, Thanh Dinh Le, Toi Van Vo, Hiep Thi Nguyen","journal-title":"Journal of Science: Advanced Materials and Devices","publisher":"Elsevier BV","published-date":1661990400,"volume":"7","issue":"4","issn":"2468-2179","title":"Fabrication of in situ crosslinking hydrogels based on oxidized alginate\/N,O-carboxymethyl chitosan\/\u03b2-tricalcium phosphate for bone regeneration","affiliations":"","references":"<ol>\n<li>Susheem Kanwar et al., Design of 3D printed scaffolds for bone tissue engineering: A review. <em>Bioprinting<\/em>. 2021; 24 :. <a href=\"https:\/\/doi.org\/10.1016\/J.BPRINT.2021.E00167\" target=\"_blank\" rel=\"noopener\">doi: 10.1016\/J.BPRINT.2021.E00167<\/a><a href=\"https:\/\/scholar.google.com\/scholar?q=Susheem+Kanwar+et+al.%2C+Design+of+3D+printed+scaffolds+for+bone+tissue+engineering%3A+A+review.+%3Cem%3EBioprinting%3C%2Fem%3E.+2021%3B+24+%3A.\" target=\"_blank\" rel=\"noopener\"><img class=\"refIcon\" style=\"width: 18px\" src=\"https:\/\/bvtn.edu.vn\/wp-content\/uploads\/2023\/07\/google-schoolar.png\" alt=\"Google Scholar\" \/><\/a><\/li>\n<li>Tao Zhang et al., Bioink design for extrusion-based bioprinting. <em>Applied Materials Today<\/em>. 2021; :. <a href=\"https:\/\/doi.org\/10.1016\/j.apmt.2021.101227\" target=\"_blank\" rel=\"noopener\">doi: 10.1016\/j.apmt.2021.101227<\/a><a href=\"https:\/\/scholar.google.com\/scholar?q=Tao+Zhang+et+al.%2C+Bioink+design+for+extrusion-based+bioprinting.+%3Cem%3EApplied+Materials+Today%3C%2Fem%3E.+2021%3B++%3A.\" target=\"_blank\" rel=\"noopener\"><img class=\"refIcon\" style=\"width: 18px\" src=\"https:\/\/bvtn.edu.vn\/wp-content\/uploads\/2023\/07\/google-schoolar.png\" alt=\"Google Scholar\" \/><\/a><\/li>\n<li>Zhan Jing et al., The role of natural polymers in bone tissue engineering.. <em>Journal of controlled release : official journal of the Controlled Release Society<\/em>. 2021; :. <a href=\"https:\/\/doi.org\/10.1016\/j.jconrel.2021.08.055\" target=\"_blank\" rel=\"noopener\">doi: 10.1016\/j.jconrel.2021.08.055<\/a><a href=\"https:\/\/scholar.google.com\/scholar?q=Zhan+Jing+et+al.%2C+The+role+of+natural+polymers+in+bone+tissue+engineering..+%3Cem%3EJournal+of+controlled+release+%3A+official+journal+of+the+Controlled+Release+Society%3C%2Fem%3E.+2021%3B++%3A.\" target=\"_blank\" rel=\"noopener\"><img class=\"refIcon\" style=\"width: 18px\" src=\"https:\/\/bvtn.edu.vn\/wp-content\/uploads\/2023\/07\/google-schoolar.png\" alt=\"Google Scholar\" \/><\/a><\/li>\n<li>S. Kalsi et al., Biomaterials for tissue engineered bone Scaffolds: A review. <em>Materials Today: Proceedings<\/em>. 2021; :. <a href=\"https:\/\/doi.org\/10.1016\/J.MATPR.2021.04.273\" target=\"_blank\" rel=\"noopener\">doi: 10.1016\/J.MATPR.2021.04.273<\/a><a href=\"https:\/\/scholar.google.com\/scholar?q=S.+Kalsi+et+al.%2C+Biomaterials+for+tissue+engineered+bone+Scaffolds%3A+A+review.+%3Cem%3EMaterials+Today%3A+Proceedings%3C%2Fem%3E.+2021%3B++%3A.\" target=\"_blank\" rel=\"noopener\"><img class=\"refIcon\" style=\"width: 18px\" src=\"https:\/\/bvtn.edu.vn\/wp-content\/uploads\/2023\/07\/google-schoolar.png\" alt=\"Google Scholar\" \/><\/a><\/li>\n<li>A. Salama et al., Recent progress in preparation and applications of chitosan\/calcium phosphate composite materials.. <em>International journal of biological macromolecules<\/em>. 2021; :. <a href=\"https:\/\/doi.org\/10.1016\/j.ijbiomac.2021.02.143\" target=\"_blank\" rel=\"noopener\">doi: 10.1016\/j.ijbiomac.2021.02.143<\/a><a href=\"https:\/\/scholar.google.com\/scholar?q=A.+Salama+et+al.%2C+Recent+progress+in+preparation+and+applications+of+chitosan%2Fcalcium+phosphate+composite+materials..+%3Cem%3EInternational+journal+of+biological+macromolecules%3C%2Fem%3E.+2021%3B++%3A.\" target=\"_blank\" rel=\"noopener\"><img class=\"refIcon\" style=\"width: 18px\" src=\"https:\/\/bvtn.edu.vn\/wp-content\/uploads\/2023\/07\/google-schoolar.png\" alt=\"Google Scholar\" \/><\/a><\/li>\n<li>A. Prasad et al., State of art review on bioabsorbable polymeric scaffolds for bone tissue engineering. <em>Materials Today: Proceedings<\/em>. 2021; :. <a href=\"https:\/\/doi.org\/10.1016\/J.MATPR.2020.11.622\" target=\"_blank\" rel=\"noopener\">doi: 10.1016\/J.MATPR.2020.11.622<\/a><a href=\"https:\/\/scholar.google.com\/scholar?q=A.+Prasad+et+al.%2C+State+of+art+review+on+bioabsorbable+polymeric+scaffolds+for+bone+tissue+engineering.+%3Cem%3EMaterials+Today%3A+Proceedings%3C%2Fem%3E.+2021%3B++%3A.\" target=\"_blank\" rel=\"noopener\"><img class=\"refIcon\" style=\"width: 18px\" src=\"https:\/\/bvtn.edu.vn\/wp-content\/uploads\/2023\/07\/google-schoolar.png\" alt=\"Google Scholar\" \/><\/a><\/li>\n<li>Min Jin et al., Polysaccharide-based Biomaterials in Tissue Engineering: A review.. <em>Tissue engineering. Part B, Reviews<\/em>. 2020; :. <a href=\"https:\/\/doi.org\/10.1089\/ten.TEB.2020.0208\" target=\"_blank\" rel=\"noopener\">doi: 10.1089\/ten.TEB.2020.0208<\/a><a href=\"https:\/\/scholar.google.com\/scholar?q=Min+Jin+et+al.%2C+Polysaccharide-based+Biomaterials+in+Tissue+Engineering%3A+A+review..+%3Cem%3ETissue+engineering.+Part+B%2C+Reviews%3C%2Fem%3E.+2020%3B++%3A.\" target=\"_blank\" rel=\"noopener\"><img class=\"refIcon\" style=\"width: 18px\" src=\"https:\/\/bvtn.edu.vn\/wp-content\/uploads\/2023\/07\/google-schoolar.png\" alt=\"Google Scholar\" \/><\/a><\/li>\n<li>Tomas Gonzalez-Fernandez et al., Alginate-Based Bioinks for 3D Bioprinting and Fabrication of Anatomically Accurate Bone Grafts.. <em>Tissue engineering. Part A<\/em>. 2020; :. <a href=\"https:\/\/doi.org\/10.1089\/ten.TEA.2020.0305\" target=\"_blank\" rel=\"noopener\">doi: 10.1089\/ten.TEA.2020.0305<\/a><a href=\"https:\/\/scholar.google.com\/scholar?q=Tomas+Gonzalez-Fernandez+et+al.%2C+Alginate-Based+Bioinks+for+3D+Bioprinting+and+Fabrication+of+Anatomically+Accurate+Bone+Grafts..+%3Cem%3ETissue+engineering.+Part+A%3C%2Fem%3E.+2020%3B++%3A.\" target=\"_blank\" rel=\"noopener\"><img class=\"refIcon\" style=\"width: 18px\" src=\"https:\/\/bvtn.edu.vn\/wp-content\/uploads\/2023\/07\/google-schoolar.png\" alt=\"Google Scholar\" \/><\/a><\/li>\n<li>Lei Ma et al., Synthesis and characterization of injectable self-healing hydrogels based on oxidized alginate-hybrid-hydroxyapatite nanoparticles and carboxymethyl chitosan.. <em>International journal of biological macromolecules<\/em>. 2020; :. <a href=\"https:\/\/doi.org\/10.1016\/j.ijbiomac.2020.10.004\" target=\"_blank\" rel=\"noopener\">doi: 10.1016\/j.ijbiomac.2020.10.004<\/a><a href=\"https:\/\/scholar.google.com\/scholar?q=Lei+Ma+et+al.%2C+Synthesis+and+characterization+of+injectable+self-healing+hydrogels+based+on+oxidized+alginate-hybrid-hydroxyapatite+nanoparticles+and+carboxymethyl+chitosan..+%3Cem%3EInternational+journal+of+biological+macromolecules%3C%2Fem%3E.+2020%3B++%3A.\" target=\"_blank\" rel=\"noopener\"><img class=\"refIcon\" style=\"width: 18px\" src=\"https:\/\/bvtn.edu.vn\/wp-content\/uploads\/2023\/07\/google-schoolar.png\" alt=\"Google Scholar\" \/><\/a><\/li>\n<li>H. D. Tran et al., A comprehensive review on polymeric hydrogel and its composite: Matrices of choice for bone and cartilage tissue engineering. <em>Journal of Industrial and Engineering Chemistry<\/em>. 2020; 89 :58-82. <a href=\"https:\/\/doi.org\/10.1016\/j.jiec.2020.06.017\" target=\"_blank\" rel=\"noopener\">doi: 10.1016\/j.jiec.2020.06.017<\/a><a href=\"https:\/\/scholar.google.com\/scholar?q=H.+D.+Tran+et+al.%2C+A+comprehensive+review+on+polymeric+hydrogel+and+its+composite%3A+Matrices+of+choice+for+bone+and+cartilage+tissue+engineering.+%3Cem%3EJournal+of+Industrial+and+Engineering+Chemistry%3C%2Fem%3E.+2020%3B+89+%3A58-82.\" target=\"_blank\" rel=\"noopener\"><img class=\"refIcon\" style=\"width: 18px\" src=\"https:\/\/bvtn.edu.vn\/wp-content\/uploads\/2023\/07\/google-schoolar.png\" alt=\"Google Scholar\" \/><\/a><\/li>\n<li>Hai Van Ho et al., Novel TOCNF reinforced injectable alginate \/ \u03b2-tricalcium phosphate microspheres for bone regeneration. <em>Materials &amp; Design<\/em>. 2020; 194 :108892. <a href=\"https:\/\/doi.org\/10.1016\/j.matdes.2020.108892\" target=\"_blank\" rel=\"noopener\">doi: 10.1016\/j.matdes.2020.108892<\/a><a href=\"https:\/\/scholar.google.com\/scholar?q=Hai+Van+Ho+et+al.%2C+Novel+TOCNF+reinforced+injectable+alginate+%2F+%CE%B2-tricalcium+phosphate+microspheres+for+bone+regeneration.+%3Cem%3EMaterials+%26+Design%3C%2Fem%3E.+2020%3B+194+%3A108892.\" target=\"_blank\" rel=\"noopener\"><img class=\"refIcon\" style=\"width: 18px\" src=\"https:\/\/bvtn.edu.vn\/wp-content\/uploads\/2023\/07\/google-schoolar.png\" alt=\"Google Scholar\" \/><\/a><\/li>\n<li>A. Le et al., Modulating biodegradation and biocompatibility of in situ crosslinked hydrogel by the integration of alginate into N,O-carboxylmethyl chitosan \u2013 aldehyde hyaluronic acid network. <em>Polymer Degradation and Stability<\/em>. 2020; 180 :109270. <a href=\"https:\/\/doi.org\/10.1016\/j.polymdegradstab.2020.109270\" target=\"_blank\" rel=\"noopener\">doi: 10.1016\/j.polymdegradstab.2020.109270<\/a><a href=\"https:\/\/scholar.google.com\/scholar?q=A.+Le+et+al.%2C+Modulating+biodegradation+and+biocompatibility+of+in+situ+crosslinked+hydrogel+by+the+integration+of+alginate+into+N%2CO-carboxylmethyl+chitosan+%E2%80%93+aldehyde+hyaluronic+acid+network.+%3Cem%3EPolymer+Degradation+and+Stability%3C%2Fem%3E.+2020%3B+180+%3A109270.\" target=\"_blank\" rel=\"noopener\"><img class=\"refIcon\" style=\"width: 18px\" src=\"https:\/\/bvtn.edu.vn\/wp-content\/uploads\/2023\/07\/google-schoolar.png\" alt=\"Google Scholar\" \/><\/a><\/li>\n<li>Aurora C. Hern\u00e1ndez-Gonz\u00e1lez et al., Alginate hydrogels for bone tissue engineering, from injectables to bioprinting: A review.. <em>Carbohydrate polymers<\/em>. 2020; 229 :115514. <a href=\"https:\/\/doi.org\/10.1016\/j.carbpol.2019.115514\" target=\"_blank\" rel=\"noopener\">doi: 10.1016\/j.carbpol.2019.115514<\/a><a href=\"https:\/\/scholar.google.com\/scholar?q=Aurora+C.+Hern%C3%A1ndez-Gonz%C3%A1lez+et+al.%2C+Alginate+hydrogels+for+bone+tissue+engineering%2C+from+injectables+to+bioprinting%3A+A+review..+%3Cem%3ECarbohydrate+polymers%3C%2Fem%3E.+2020%3B+229+%3A115514.\" target=\"_blank\" rel=\"noopener\"><img class=\"refIcon\" style=\"width: 18px\" src=\"https:\/\/bvtn.edu.vn\/wp-content\/uploads\/2023\/07\/google-schoolar.png\" alt=\"Google Scholar\" \/><\/a><\/li>\n<li>N. Nguyen et al., The effect of oxidation degree and volume ratio of components on properties and applications of in situ cross-linking hydrogels based on chitosan and hyaluronic acid.. <em>Materials science &amp; engineering. C, Materials for biological applications<\/em>. 2019; 103 :109670. <a href=\"https:\/\/doi.org\/10.1016\/J.MSEC.2019.04.049\" target=\"_blank\" rel=\"noopener\">doi: 10.1016\/J.MSEC.2019.04.049<\/a><a href=\"https:\/\/scholar.google.com\/scholar?q=N.+Nguyen+et+al.%2C+The+effect+of+oxidation+degree+and+volume+ratio+of+components+on+properties+and+applications+of+in+situ+cross-linking+hydrogels+based+on+chitosan+and+hyaluronic+acid..+%3Cem%3EMaterials+science+%26+engineering.+C%2C+Materials+for+biological+applications%3C%2Fem%3E.+2019%3B+103+%3A109670.\" target=\"_blank\" rel=\"noopener\"><img class=\"refIcon\" style=\"width: 18px\" src=\"https:\/\/bvtn.edu.vn\/wp-content\/uploads\/2023\/07\/google-schoolar.png\" alt=\"Google Scholar\" \/><\/a><\/li>\n<li>Gopal Shankar Krishnakumar et al., Importance of crosslinking strategies in designing smart biomaterials for bone tissue engineering: A systematic review.. <em>Materials science &amp; engineering. C, Materials for biological applications<\/em>. 2019; 96 :941-954. <a href=\"https:\/\/doi.org\/10.1016\/j.msec.2018.11.081\" target=\"_blank\" rel=\"noopener\">doi: 10.1016\/j.msec.2018.11.081<\/a><a href=\"https:\/\/scholar.google.com\/scholar?q=Gopal+Shankar+Krishnakumar+et+al.%2C+Importance+of+crosslinking+strategies+in+designing+smart+biomaterials+for+bone+tissue+engineering%3A+A+systematic+review..+%3Cem%3EMaterials+science+%26+engineering.+C%2C+Materials+for+biological+applications%3C%2Fem%3E.+2019%3B+96+%3A941-954.\" target=\"_blank\" rel=\"noopener\"><img class=\"refIcon\" style=\"width: 18px\" src=\"https:\/\/bvtn.edu.vn\/wp-content\/uploads\/2023\/07\/google-schoolar.png\" alt=\"Google Scholar\" \/><\/a><\/li>\n<li>Z. Emami et al., Controlling alginate oxidation conditions for making alginate-gelatin hydrogels.. <em>Carbohydrate polymers<\/em>. 2018; 198 :509-517. <a href=\"https:\/\/doi.org\/10.1016\/j.carbpol.2018.06.080\" target=\"_blank\" rel=\"noopener\">doi: 10.1016\/j.carbpol.2018.06.080<\/a><a href=\"https:\/\/scholar.google.com\/scholar?q=Z.+Emami+et+al.%2C+Controlling+alginate+oxidation+conditions+for+making+alginate-gelatin+hydrogels..+%3Cem%3ECarbohydrate+polymers%3C%2Fem%3E.+2018%3B+198+%3A509-517.\" target=\"_blank\" rel=\"noopener\"><img class=\"refIcon\" style=\"width: 18px\" src=\"https:\/\/bvtn.edu.vn\/wp-content\/uploads\/2023\/07\/google-schoolar.png\" alt=\"Google Scholar\" \/><\/a><\/li>\n<li>Lin Zhu et al., Properties of a novel carboxymethyl chitosan derived from silkworm pupa.. <em>Archives of insect biochemistry and physiology<\/em>. 2018; 99 2 :e21499. <a href=\"https:\/\/doi.org\/10.1002\/arch.21499\" target=\"_blank\" rel=\"noopener\">doi: 10.1002\/arch.21499<\/a><a href=\"https:\/\/scholar.google.com\/scholar?q=Lin+Zhu+et+al.%2C+Properties+of+a+novel+carboxymethyl+chitosan+derived+from+silkworm+pupa..+%3Cem%3EArchives+of+insect+biochemistry+and+physiology%3C%2Fem%3E.+2018%3B+99+2+%3Ae21499.\" target=\"_blank\" rel=\"noopener\"><img class=\"refIcon\" style=\"width: 18px\" src=\"https:\/\/bvtn.edu.vn\/wp-content\/uploads\/2023\/07\/google-schoolar.png\" alt=\"Google Scholar\" \/><\/a><\/li>\n<li>Supachai Reakasame et al., Oxidized Alginate-Based Hydrogels for Tissue Engineering Applications: A Review.. <em>Biomacromolecules<\/em>. 2018; 19 1 :3-21. <a href=\"https:\/\/doi.org\/10.1021\/acs.biomac.7b01331\" target=\"_blank\" rel=\"noopener\">doi: 10.1021\/acs.biomac.7b01331<\/a><a href=\"https:\/\/scholar.google.com\/scholar?q=Supachai+Reakasame+et+al.%2C+Oxidized+Alginate-Based+Hydrogels+for+Tissue+Engineering+Applications%3A+A+Review..+%3Cem%3EBiomacromolecules%3C%2Fem%3E.+2018%3B+19+1+%3A3-21.\" target=\"_blank\" rel=\"noopener\"><img class=\"refIcon\" style=\"width: 18px\" src=\"https:\/\/bvtn.edu.vn\/wp-content\/uploads\/2023\/07\/google-schoolar.png\" alt=\"Google Scholar\" \/><\/a><\/li>\n<li>E. Axpe et al., Applications of Alginate-Based Bioinks in 3D Bioprinting. <em>International Journal of Molecular Sciences<\/em>. 2016; 17 :. <a href=\"https:\/\/doi.org\/10.3390\/ijms17121976\" target=\"_blank\" rel=\"noopener\">doi: 10.3390\/ijms17121976<\/a><a href=\"https:\/\/scholar.google.com\/scholar?q=E.+Axpe+et+al.%2C+Applications+of+Alginate-Based+Bioinks+in+3D+Bioprinting.+%3Cem%3EInternational+Journal+of+Molecular+Sciences%3C%2Fem%3E.+2016%3B+17+%3A.\" target=\"_blank\" rel=\"noopener\"><img class=\"refIcon\" style=\"width: 18px\" src=\"https:\/\/bvtn.edu.vn\/wp-content\/uploads\/2023\/07\/google-schoolar.png\" alt=\"Google Scholar\" \/><\/a><\/li>\n<li>R. LogithKumar et al., A review of chitosan and its derivatives in bone tissue engineering.. <em>Carbohydrate polymers<\/em>. 2016; 151 :172-188. <a href=\"https:\/\/doi.org\/10.1016\/j.carbpol.2016.05.049\" target=\"_blank\" rel=\"noopener\">doi: 10.1016\/j.carbpol.2016.05.049<\/a><a href=\"https:\/\/scholar.google.com\/scholar?q=R.+LogithKumar+et+al.%2C+A+review+of+chitosan+and+its+derivatives+in+bone+tissue+engineering..+%3Cem%3ECarbohydrate+polymers%3C%2Fem%3E.+2016%3B+151+%3A172-188.\" target=\"_blank\" rel=\"noopener\"><img class=\"refIcon\" style=\"width: 18px\" src=\"https:\/\/bvtn.edu.vn\/wp-content\/uploads\/2023\/07\/google-schoolar.png\" alt=\"Google Scholar\" \/><\/a><\/li>\n<li>Xiujuan Zhao et al., Reactive electrospinning of composite nanofibers of carboxymethyl chitosan cross-linked by alginate dialdehyde with the aid of polyethylene oxide.. <em>Carbohydrate polymers<\/em>. 2016; 148 :98-106. <a href=\"https:\/\/doi.org\/10.1016\/j.carbpol.2016.04.051\" target=\"_blank\" rel=\"noopener\">doi: 10.1016\/j.carbpol.2016.04.051<\/a><a href=\"https:\/\/scholar.google.com\/scholar?q=Xiujuan+Zhao+et+al.%2C+Reactive+electrospinning+of+composite+nanofibers+of+carboxymethyl+chitosan+cross-linked+by+alginate+dialdehyde+with+the+aid+of+polyethylene+oxide..+%3Cem%3ECarbohydrate+polymers%3C%2Fem%3E.+2016%3B+148+%3A98-106.\" target=\"_blank\" rel=\"noopener\"><img class=\"refIcon\" style=\"width: 18px\" src=\"https:\/\/bvtn.edu.vn\/wp-content\/uploads\/2023\/07\/google-schoolar.png\" alt=\"Google Scholar\" \/><\/a><\/li>\n<li>Chhavi Sharma et al., Fabrication and characterization of novel nano-biocomposite scaffold of chitosan-gelatin-alginate-hydroxyapatite for bone tissue engineering.. <em>Materials science &amp; engineering. C, Materials for biological applications<\/em>. 2016; 64 :416-427. <a href=\"https:\/\/doi.org\/10.1016\/j.msec.2016.03.060\" target=\"_blank\" rel=\"noopener\">doi: 10.1016\/j.msec.2016.03.060<\/a><a href=\"https:\/\/scholar.google.com\/scholar?q=Chhavi+Sharma+et+al.%2C+Fabrication+and+characterization+of+novel+nano-biocomposite+scaffold+of+chitosan-gelatin-alginate-hydroxyapatite+for+bone+tissue+engineering..+%3Cem%3EMaterials+science+%26+engineering.+C%2C+Materials+for+biological+applications%3C%2Fem%3E.+2016%3B+64+%3A416-427.\" target=\"_blank\" rel=\"noopener\"><img class=\"refIcon\" style=\"width: 18px\" src=\"https:\/\/bvtn.edu.vn\/wp-content\/uploads\/2023\/07\/google-schoolar.png\" alt=\"Google Scholar\" \/><\/a><\/li>\n<li>Avik Sarker et al., HAp granules encapsulated oxidized alginate-gelatin-biphasic calcium phosphate hydrogel for bone regeneration.. <em>International journal of biological macromolecules<\/em>. 2015; 81 :898-911. <a href=\"https:\/\/doi.org\/10.1016\/j.ijbiomac.2015.09.029\" target=\"_blank\" rel=\"noopener\">doi: 10.1016\/j.ijbiomac.2015.09.029<\/a><a href=\"https:\/\/scholar.google.com\/scholar?q=Avik+Sarker+et+al.%2C+HAp+granules+encapsulated+oxidized+alginate-gelatin-biphasic+calcium+phosphate+hydrogel+for+bone+regeneration..+%3Cem%3EInternational+journal+of+biological+macromolecules%3C%2Fem%3E.+2015%3B+81+%3A898-911.\" target=\"_blank\" rel=\"noopener\"><img class=\"refIcon\" style=\"width: 18px\" src=\"https:\/\/bvtn.edu.vn\/wp-content\/uploads\/2023\/07\/google-schoolar.png\" alt=\"Google Scholar\" \/><\/a><\/li>\n<li>Yufeng Zhang et al., Determination of a critical size calvarial defect in senile osteoporotic mice model based on in vivo micro-computed tomography and histological evaluation.. <em>Archives of gerontology and geriatrics<\/em>. 2015; 61 1 :44-55. <a href=\"https:\/\/doi.org\/10.1016\/j.archger.2015.01.019\" target=\"_blank\" rel=\"noopener\">doi: 10.1016\/j.archger.2015.01.019<\/a><a href=\"https:\/\/scholar.google.com\/scholar?q=Yufeng+Zhang+et+al.%2C+Determination+of+a+critical+size+calvarial+defect+in+senile+osteoporotic+mice+model+based+on+in+vivo+micro-computed+tomography+and+histological+evaluation..+%3Cem%3EArchives+of+gerontology+and+geriatrics%3C%2Fem%3E.+2015%3B+61+1+%3A44-55.\" target=\"_blank\" rel=\"noopener\"><img class=\"refIcon\" style=\"width: 18px\" src=\"https:\/\/bvtn.edu.vn\/wp-content\/uploads\/2023\/07\/google-schoolar.png\" alt=\"Google Scholar\" \/><\/a><\/li>\n<li>V. Campana et al., Bone substitutes in orthopaedic surgery: from basic science to clinical practice. <em>Journal of Materials Science. Materials in Medicine<\/em>. 2014; 25 :2445 - 2461. <a href=\"https:\/\/doi.org\/10.1007\/s10856-014-5240-2\" target=\"_blank\" rel=\"noopener\">doi: 10.1007\/s10856-014-5240-2<\/a><a href=\"https:\/\/scholar.google.com\/scholar?q=V.+Campana+et+al.%2C+Bone+substitutes+in+orthopaedic+surgery%3A+from+basic+science+to+clinical+practice.+%3Cem%3EJournal+of+Materials+Science.+Materials+in+Medicine%3C%2Fem%3E.+2014%3B+25+%3A2445+-+2461.\" target=\"_blank\" rel=\"noopener\"><img class=\"refIcon\" style=\"width: 18px\" src=\"https:\/\/bvtn.edu.vn\/wp-content\/uploads\/2023\/07\/google-schoolar.png\" alt=\"Google Scholar\" \/><\/a><\/li>\n<li>S. Samavedi et al., Calcium phosphate ceramics in bone tissue engineering: a review of properties and their influence on cell behavior.. <em>Acta biomaterialia<\/em>. 2013; 9 9 :8037-45. <a href=\"https:\/\/doi.org\/10.1016\/j.actbio.2013.06.014\" target=\"_blank\" rel=\"noopener\">doi: 10.1016\/j.actbio.2013.06.014<\/a><a href=\"https:\/\/scholar.google.com\/scholar?q=S.+Samavedi+et+al.%2C+Calcium+phosphate+ceramics+in+bone+tissue+engineering%3A+a+review+of+properties+and+their+influence+on+cell+behavior..+%3Cem%3EActa+biomaterialia%3C%2Fem%3E.+2013%3B+9+9+%3A8037-45.\" target=\"_blank\" rel=\"noopener\"><img class=\"refIcon\" style=\"width: 18px\" src=\"https:\/\/bvtn.edu.vn\/wp-content\/uploads\/2023\/07\/google-schoolar.png\" alt=\"Google Scholar\" \/><\/a><\/li>\n<li>Laxmi Upadhyaya et al., Biomedical applications of carboxymethyl chitosans.. <em>Carbohydrate polymers<\/em>. 2013; 91 1 :452-66. <a href=\"https:\/\/doi.org\/10.1016\/j.carbpol.2012.07.076\" target=\"_blank\" rel=\"noopener\">doi: 10.1016\/j.carbpol.2012.07.076<\/a><a href=\"https:\/\/scholar.google.com\/scholar?q=Laxmi+Upadhyaya+et+al.%2C+Biomedical+applications+of+carboxymethyl+chitosans..+%3Cem%3ECarbohydrate+polymers%3C%2Fem%3E.+2013%3B+91+1+%3A452-66.\" target=\"_blank\" rel=\"noopener\"><img class=\"refIcon\" style=\"width: 18px\" src=\"https:\/\/bvtn.edu.vn\/wp-content\/uploads\/2023\/07\/google-schoolar.png\" alt=\"Google Scholar\" \/><\/a><\/li>\n<li>Xingyi Li et al., A covalently crosslinked polysaccharide hydrogel for potential applications in drug delivery and tissue engineering. <em>Journal of Materials Science: Materials in Medicine<\/em>. 2012; 23 :2857-2865. <a href=\"https:\/\/doi.org\/10.1007\/s10856-012-4757-5\" target=\"_blank\" rel=\"noopener\">doi: 10.1007\/s10856-012-4757-5<\/a><a href=\"https:\/\/scholar.google.com\/scholar?q=Xingyi+Li+et+al.%2C+A+covalently+crosslinked+polysaccharide+hydrogel+for+potential+applications+in+drug+delivery+and+tissue+engineering.+%3Cem%3EJournal+of+Materials+Science%3A+Materials+in+Medicine%3C%2Fem%3E.+2012%3B+23+%3A2857-2865.\" target=\"_blank\" rel=\"noopener\"><img class=\"refIcon\" style=\"width: 18px\" src=\"https:\/\/bvtn.edu.vn\/wp-content\/uploads\/2023\/07\/google-schoolar.png\" alt=\"Google Scholar\" \/><\/a><\/li>\n<li>Yingyu Zhou et al., Radiation synthesis of gelatin\/CM-chitosan\/\u03b2-tricalcium phosphate composite scaffold for bone tissue engineering. <em>Materials Science and Engineering: C<\/em>. 2012; 32 :994-1000. <a href=\"https:\/\/doi.org\/10.1016\/J.MSEC.2012.02.029\" target=\"_blank\" rel=\"noopener\">doi: 10.1016\/J.MSEC.2012.02.029<\/a><a href=\"https:\/\/scholar.google.com\/scholar?q=Yingyu+Zhou+et+al.%2C+Radiation+synthesis+of+gelatin%2FCM-chitosan%2F%CE%B2-tricalcium+phosphate+composite+scaffold+for+bone+tissue+engineering.+%3Cem%3EMaterials+Science+and+Engineering%3A+C%3C%2Fem%3E.+2012%3B+32+%3A994-1000.\" target=\"_blank\" rel=\"noopener\"><img class=\"refIcon\" style=\"width: 18px\" src=\"https:\/\/bvtn.edu.vn\/wp-content\/uploads\/2023\/07\/google-schoolar.png\" alt=\"Google Scholar\" \/><\/a><\/li>\n<li>L. B\u0113rzi\u0146a-Cimdi\u0146a et al., Research of Calcium Phosphates Using Fourier Transform Infrared Spectroscopy. . 2012; :. <a href=\"https:\/\/doi.org\/10.5772\/36942\" target=\"_blank\" rel=\"noopener\">doi: 10.5772\/36942<\/a><a href=\"https:\/\/scholar.google.com\/scholar?q=L.+B%C4%93rzi%C5%86a-Cimdi%C5%86a+et+al.%2C+Research+of+Calcium+Phosphates+Using+Fourier+Transform+Infrared+Spectroscopy.+%3Cem%3E%3C%2Fem%3E.+2012%3B++%3A.\" target=\"_blank\" rel=\"noopener\"><img class=\"refIcon\" style=\"width: 18px\" src=\"https:\/\/bvtn.edu.vn\/wp-content\/uploads\/2023\/07\/google-schoolar.png\" alt=\"Google Scholar\" \/><\/a><\/li>\n<li>S. Bose et al., Calcium phosphate ceramic systems in growth factor and drug delivery for bone tissue engineering: a review.. <em>Acta biomaterialia<\/em>. 2012; 8 4 :1401-21. <a href=\"https:\/\/doi.org\/10.1016\/j.actbio.2011.11.017\" target=\"_blank\" rel=\"noopener\">doi: 10.1016\/j.actbio.2011.11.017<\/a><a href=\"https:\/\/scholar.google.com\/scholar?q=S.+Bose+et+al.%2C+Calcium+phosphate+ceramic+systems+in+growth+factor+and+drug+delivery+for+bone+tissue+engineering%3A+a+review..+%3Cem%3EActa+biomaterialia%3C%2Fem%3E.+2012%3B+8+4+%3A1401-21.\" target=\"_blank\" rel=\"noopener\"><img class=\"refIcon\" style=\"width: 18px\" src=\"https:\/\/bvtn.edu.vn\/wp-content\/uploads\/2023\/07\/google-schoolar.png\" alt=\"Google Scholar\" \/><\/a><\/li>\n<li>Adem \u00c7inarli et al., Synthesis, spectral characterizations and antimicrobial activity of some Schiff bases of 4-chloro-2-aminophenol. <em>Bulletin of The Chemical Society of Ethiopia<\/em>. 2011; 25 :. <a href=\"https:\/\/doi.org\/10.4314\/BCSE.V25I3.68593\" target=\"_blank\" rel=\"noopener\">doi: 10.4314\/BCSE.V25I3.68593<\/a><a href=\"https:\/\/scholar.google.com\/scholar?q=Adem+%C3%87inarli+et+al.%2C+Synthesis%2C+spectral+characterizations+and+antimicrobial+activity+of+some+Schiff+bases+of+4-chloro-2-aminophenol.+%3Cem%3EBulletin+of+The+Chemical+Society+of+Ethiopia%3C%2Fem%3E.+2011%3B+25+%3A.\" target=\"_blank\" rel=\"noopener\"><img class=\"refIcon\" style=\"width: 18px\" src=\"https:\/\/bvtn.edu.vn\/wp-content\/uploads\/2023\/07\/google-schoolar.png\" alt=\"Google Scholar\" \/><\/a><\/li>\n<li>Jin Ye et al., Critical-size calvarial bone defects healing in a mouse model with silk scaffolds and SATB2-modified iPSCs.. <em>Biomaterials<\/em>. 2011; 32 22 :5065-76. <a href=\"https:\/\/doi.org\/10.1016\/j.biomaterials.2011.03.053\" target=\"_blank\" rel=\"noopener\">doi: 10.1016\/j.biomaterials.2011.03.053<\/a><a href=\"https:\/\/scholar.google.com\/scholar?q=Jin+Ye+et+al.%2C+Critical-size+calvarial+bone+defects+healing+in+a+mouse+model+with+silk+scaffolds+and+SATB2-modified+iPSCs..+%3Cem%3EBiomaterials%3C%2Fem%3E.+2011%3B+32+22+%3A5065-76.\" target=\"_blank\" rel=\"noopener\"><img class=\"refIcon\" style=\"width: 18px\" src=\"https:\/\/bvtn.edu.vn\/wp-content\/uploads\/2023\/07\/google-schoolar.png\" alt=\"Google Scholar\" \/><\/a><\/li>\n<li>A. R. Costa-Pinto et al., Scaffolds based bone tissue engineering: the role of chitosan.. <em>Tissue engineering. Part B, Reviews<\/em>. 2011; 17 5 :331-47. <a href=\"https:\/\/doi.org\/10.1089\/ten.teb.2010.0704\" target=\"_blank\" rel=\"noopener\">doi: 10.1089\/ten.teb.2010.0704<\/a><a href=\"https:\/\/scholar.google.com\/scholar?q=A.+R.+Costa-Pinto+et+al.%2C+Scaffolds+based+bone+tissue+engineering%3A+the+role+of+chitosan..+%3Cem%3ETissue+engineering.+Part+B%2C+Reviews%3C%2Fem%3E.+2011%3B+17+5+%3A331-47.\" target=\"_blank\" rel=\"noopener\"><img class=\"refIcon\" style=\"width: 18px\" src=\"https:\/\/bvtn.edu.vn\/wp-content\/uploads\/2023\/07\/google-schoolar.png\" alt=\"Google Scholar\" \/><\/a><\/li>\n<li>P. Gomes et al., Rodent models in bone-related research: the relevance of calvarial defects in the assessment of bone regeneration strategies. <em>Laboratory Animals<\/em>. 2011; 45 :14 - 24. <a href=\"https:\/\/doi.org\/10.1258\/la.2010.010085\" target=\"_blank\" rel=\"noopener\">doi: 10.1258\/la.2010.010085<\/a><a href=\"https:\/\/scholar.google.com\/scholar?q=P.+Gomes+et+al.%2C+Rodent+models+in+bone-related+research%3A+the+relevance+of+calvarial+defects+in+the+assessment+of+bone+regeneration+strategies.+%3Cem%3ELaboratory+Animals%3C%2Fem%3E.+2011%3B+45+%3A14+-+24.\" target=\"_blank\" rel=\"noopener\"><img class=\"refIcon\" style=\"width: 18px\" src=\"https:\/\/bvtn.edu.vn\/wp-content\/uploads\/2023\/07\/google-schoolar.png\" alt=\"Google Scholar\" \/><\/a><\/li>\n<li>K. Cai et al., Physical and Biological Properties of a Novel Hydrogel Composite Based on Oxidized Alginate, Gelatin and Tricalcium Phosphate for Bone Tissue Engineering. <em>Advanced Engineering Materials<\/em>. 2007; 9 :. <a href=\"https:\/\/doi.org\/10.1002\/adem.200700222\" target=\"_blank\" rel=\"noopener\">doi: 10.1002\/adem.200700222<\/a><a href=\"https:\/\/scholar.google.com\/scholar?q=K.+Cai+et+al.%2C+Physical+and+Biological+Properties+of+a+Novel+Hydrogel+Composite+Based+on+Oxidized+Alginate%2C+Gelatin+and+Tricalcium+Phosphate+for+Bone+Tissue+Engineering.+%3Cem%3EAdvanced+Engineering+Materials%3C%2Fem%3E.+2007%3B+9+%3A.\" target=\"_blank\" rel=\"noopener\"><img class=\"refIcon\" style=\"width: 18px\" src=\"https:\/\/bvtn.edu.vn\/wp-content\/uploads\/2023\/07\/google-schoolar.png\" alt=\"Google Scholar\" \/><\/a><\/li>\n<li>Sung-Ching Chen et al., A novel pH-sensitive hydrogel composed of N,O-carboxymethyl chitosan and alginate cross-linked by genipin for protein drug delivery.. <em>Journal of controlled release : official journal of the Controlled Release Society<\/em>. 2004; 96 2 :285-300. <a href=\"https:\/\/doi.org\/10.1016\/J.JCONREL.2004.02.002\" target=\"_blank\" rel=\"noopener\">doi: 10.1016\/J.JCONREL.2004.02.002<\/a><a href=\"https:\/\/scholar.google.com\/scholar?q=Sung-Ching+Chen+et+al.%2C+A+novel+pH-sensitive+hydrogel+composed+of+N%2CO-carboxymethyl+chitosan+and+alginate+cross-linked+by+genipin+for+protein+drug+delivery..+%3Cem%3EJournal+of+controlled+release+%3A+official+journal+of+the+Controlled+Release+Society%3C%2Fem%3E.+2004%3B+96+2+%3A285-300.\" target=\"_blank\" rel=\"noopener\"><img class=\"refIcon\" style=\"width: 18px\" src=\"https:\/\/bvtn.edu.vn\/wp-content\/uploads\/2023\/07\/google-schoolar.png\" alt=\"Google Scholar\" \/><\/a><\/li>\n<\/ol>\n","tldr":"","research-type":"","bibtex":"<p>@Article{Vu2022FabricationOI,<br \/>\nDOI = {10.1016\/j.jsamd.2022.100503}, author = {B. Vu and Van Hua and Tuan N. Tang and Nhi Ngoc-Thao Dang and Hang Thi-Thuy Cao and T. Phan and Hanh Thi-Kieu Ta and V. Pham and Q. Tran and Thanh Dinh Le and Toi Van Vo and H. T. Nguyen},<br \/>\nbooktitle = {Journal of Science: Advanced Materials and Devices},<br \/>\njournal = {Journal of Science: Advanced Materials and Devices},<br \/>\ntitle = {Fabrication of in situ crosslinking hydrogels based on oxidized alginate\/N,O-carboxymethyl chitosan\/\u03b2-tricalcium phosphate for bone regeneration},<br \/>\nyear = {2022}<br \/>\n}<\/p>\n"},"loai-nghien-cuu":[124],"class_list":["post-20052","nghien-cuu","type-nghien-cuu","status-publish","hentry","loai-nghien-cuu-quoc-te"],"_links":{"self":[{"href":"https:\/\/bvtn.edu.vn\/en\/wp-json\/wp\/v2\/nghien-cuu\/20052","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bvtn.edu.vn\/en\/wp-json\/wp\/v2\/nghien-cuu"}],"about":[{"href":"https:\/\/bvtn.edu.vn\/en\/wp-json\/wp\/v2\/types\/nghien-cuu"}],"replies":[{"embeddable":true,"href":"https:\/\/bvtn.edu.vn\/en\/wp-json\/wp\/v2\/comments?post=20052"}],"version-history":[{"count":0,"href":"https:\/\/bvtn.edu.vn\/en\/wp-json\/wp\/v2\/nghien-cuu\/20052\/revisions"}],"wp:attachment":[{"href":"https:\/\/bvtn.edu.vn\/en\/wp-json\/wp\/v2\/media?parent=20052"}],"wp:term":[{"taxonomy":"loai-nghien-cuu","embeddable":true,"href":"https:\/\/bvtn.edu.vn\/en\/wp-json\/wp\/v2\/loai-nghien-cuu?post=20052"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}